Isotretinoin's Label Never Demanded Monthly Blood Draws

A new JAMA Dermatology viewpoint argues most isotretinoin patients don't need routine liver and lipid testing, but the drug's FDA-approved label never actually specified the monthly schedule that became dermatology's default. That habit was built by clinical culture over three decades, not by regulation, and it is the fourth step in a ten-year sequence of evidence pulling practice back toward what the label always allowed.